H2N2V1, 1957, Analysis, bibRecord, 000170

Isolation of an influenza A virus of unusual subtype (H1N7) from pigs in England, and the subsequent experimental transmission from pig to pig

Identifieur interne : 000170 ( 1957/Analysis ); précédent : 000169; suivant : 000171

Isolation of an influenza A virus of unusual subtype (H1N7) from pigs in England, and the subsequent experimental transmission from pig to pig

Auteurs : I. H. Brown [Royaume-Uni] ; D. J. Alexander [Royaume-Uni] ; P. Chakraverty [Royaume-Uni] ; P. A. Harris [Royaume-Uni] ; R. J. Manvell [Royaume-Uni]

Source :

Veterinary Microbiology [ 0378-1135 ] ; 1994.

RBID : ISTEX:A550D8F1CB5CD9D8C4D566D23AE5922C48CBEB4E

English descriptors

Teeft :
- Avian, Avian influenza, Avian population, Blood cells, Clinical disease, Contact pigs, Control animals, Embryonated fowls, Great britain, Haemagglutinating agents, Haemagglutination inhibition, Human population, Influenza, Influenza virus, Influenza viruses, Limited virus multiplication, Matrix antigen, Microbiology, Nasal, Nasal passages, Nasal swabs, Neuraminidase, Neuraminidase inhibition, Other species, Outbreak, Pig, Sentinel, Sentinel animals, Sentinel pigs, Serological, Single animals, Subtypes, Swine, Veterinary microbiology, Virus, Virus antigenically, Virus isolation.

Abstract

Abstract: A novel H1N7 influenza virus (A/swine/Eng/191973/92) was isolated from nasal swabs collected from two pigs on a farm where there had been recent clinical disease due to infection with an H1N1 virus (A/swine/Eng/195852/92). Antigenically, the haemagglutinin (HA) of the H1N7 virus was related most closely to the HA of A/USSR/90/77, whilst the neuraminidase (NA) appeared to be related most closely to the NA of A/equine/Prague/1/56 (H7N7). Pigs infected experimentally with A/swine/Eng/191973/92 developed mild clinical signs, excreted virus into the nasal passages for up to nine days after infection, appeared normal at necropsy, transmitted the virus to sentinel pigs, but seven out of eight pigs failed to seroconvert. These findings suggest that the H1N7 virus has a low pathogenicity for pigs, resulting in limited virus multiplication which is insufficient to stimulate a detectable primary humoral immune response.

Url:

https://api.istex.fr/ark:/67375/6H6-1W9FH8B3-N/fulltext.pdf

DOI: 10.1016/0378-1135(94)90093-0

Affiliations:

Royaume-Uni

Links toward previous steps (curation, corpus...)

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to stream Main, to step Exploration: 001D99
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Links to Exploration step

ISTEX:A550D8F1CB5CD9D8C4D566D23AE5922C48CBEB4E

Le document en format XML

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<front><div type="abstract" xml:lang="en">Abstract: A novel H1N7 influenza virus (A/swine/Eng/191973/92) was isolated from nasal swabs collected from two pigs on a farm where there had been recent clinical disease due to infection with an H1N1 virus (A/swine/Eng/195852/92). Antigenically, the haemagglutinin (HA) of the H1N7 virus was related most closely to the HA of A/USSR/90/77, whilst the neuraminidase (NA) appeared to be related most closely to the NA of A/equine/Prague/1/56 (H7N7). Pigs infected experimentally with A/swine/Eng/191973/92 developed mild clinical signs, excreted virus into the nasal passages for up to nine days after infection, appeared normal at necropsy, transmitted the virus to sentinel pigs, but seven out of eight pigs failed to seroconvert. These findings suggest that the H1N7 virus has a low pathogenicity for pigs, resulting in limited virus multiplication which is insufficient to stimulate a detectable primary humoral immune response.</div>
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Isolation of an influenza A virus of unusual subtype (H1N7) from pigs in England, and the subsequent experimental transmission from pig to pig

Isolation of an influenza A virus of unusual subtype (H1N7) from pigs in England, and the subsequent experimental transmission from pig to pig

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

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